Riboflavin Tetrabutyrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

核黄素四丁酸酯是一种亲脂性黄素衍生物。核黄素四丁酸酯具有抗氧化和去除脂质过氧化物的活性。

Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.(In Vitro):Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction .(In Vivo):Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver, and so on through the inhibition of lipid peroxide, resulting in a decrease of the elevated serum lipid. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration induces an increased beta-oxidation of fatty acid in the liver. Feeding of Riboflavin Tetrabutyrate causes an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected .

Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction.

Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver .

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Immunology/Inflammation

ROS

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752-56-7

656.733

C33H44N4O10

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (152.27 mM)

CCCC(=O)OC[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@H](Cn1c2cc(C)c(C)cc2nc2c(O)nc(=O)nc12)OC(=O)CCC

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(-20℃)

With Ice Pack

≥ 2 years